Cathodoluminescence imaging on quartz in sandstone

Integrated correlative light and electron microscopy: A new technique for geological materials

Posted by Delmic on May 3, 2018 3:00:00 PM

Integrated correlative light and electron microscopy (iCLEM) is a technique, in which both fluorescence imaging and electron imaging can be performed on one instrument without needing to transfer the sample. Correlative microscopy approach is being used worldwide for cancer research, in marine biology, neuroscience, and cell biology. Recently this technique has also been applied in the field of geology to gain an insight into the sedimentary organic matter in geological materials.

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Topics: correlative microscopy, Presentation, Geology, SECOM, fluorescence microscopy, electron microscopy, iclem, scanning electron microscope, correlative light and electron microscopy, geological materials


How Does Correlative Microscopy Work?

Posted by Delmic on Apr 13, 2018 1:30:00 PM

Nowadays it has become crucial for life scientists to gain structural and functional data about the sample in order to understand the biological processes happening at the scale of the nanometer. Light or fluorescence microscopy made it possible for the researchers to detect the functional information and image different colors and parts of the cell. It provides the data to understand the dynamics of the cell, however, the diffraction limit of light doesn’t allow distinguishing objects that are smaller than the wavelength of light. That is when the life scientists turn to electron microscopy, which provides the structural information in a high resolution.

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Topics: correlative microscopy, SECOM, video, clem, correlative light electron microscope, microscopy solution, integrated clem, fluorescence microscopy, electron microscopy, iclem, life science microscope, scanning electron microscope, correlative light and electron microscopy, clem video


Correlative light and electron microscopy on SECOM platform: benefits for the research

Posted by Delmic on Feb 21, 2018 2:44:38 PM

How can your research benefit from correlative light and electron microscopy? Why is this technique becoming increasingly attractive to many scientists in different fields of research? This is the main focus of the newest video, in which our application specialist Sangeetha Hari explains the main advantages of correlative light and electron microscopy on the SECOM, a unique microscopy solution for life sciences

 

 

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Topics: correlative microscopy, SECOM, video, clem, correlative light electron microscope, microscopy solution, integrated clem, fluorescence microscopy, electron microscopy, iclem, life science microscope, scanning electron microscope, correlative light and electron microscopy, clem video


Potential of correlative light and electron microscopy for understanding Diabetes Type 1

Posted by Vera Lanskaya on Feb 19, 2018 11:59:04 AM

Diabetes Type 1, one of the two widely spread forms, is an autoimmune decease, which is caused by destruction of insulin-producing beta cells in pancreas. This type of Diabetes is called insulin-dependent: the body’s immune system attacks the beta cells located in the Islets of Langerhans in the pancreas, which normally maintain the blood sugar levels by producing the necessary amount of insulin. When the islets do not release the insulin, the amount of glucose in the blood builds up. This results in cells suffering and dying from the lack of glucose and high blood sugar levels, which makes multiple organs collapse and lead to coma and death.

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Topics: correlative microscopy, life sciences, SECOM, clem, correlative light electron microscope


An inside look at the department of Imaging Physics, TU Delft: The breeding ground for innovations in iCLEM

Posted by Delmic on Sep 28, 2017 4:29:42 PM

Understanding the relationship between structure and function in biology requires continuous developments in the field of microscopy. While electron microscopes and fluorescence microscopes have been go-to techniques for studying organic samples at a high resolution, individually they fall short in offering the exhaustive data needed for truly in-depth life science research.

In 2011, the Charged Particle Optics group at TU Delft completed the development of the SECOM. This system integrates a light and electron microscope, thus combining the labelling capabilities of fluorescence microscopy with the high-resolution nanoscale data obtained from electron microscopy. Six years later, the department of Imaging Physics houses no less than five SECOM systems.

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Topics: correlative microscopy, life sciences, microscopy, SECOM


Thoughts on the various applications, techniques, and complications to be discovered in the fascinating fields of both cathodoluminescence and correlative light and electron microscopy.

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