Cathodoluminescence imaging on quartz in sandstone

Correlative light and electron microscopy on SECOM platform: benefits for the research

Posted by Delmic on Feb 21, 2018 2:44:38 PM

How can your research benefit from correlative light and electron microscopy? Why is this technique becoming increasingly attractive to many scientists in different fields of research? This is the main focus of the newest video, in which our application specialist Sangeetha Hari explains the main advantages of correlative light and electron microscopy on the SECOM, a unique microscopy solution for life sciences



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Topics: correlative microscopy, SECOM, video, clem, correlative light electron microscope, microscopy solution, integrated clem, fluorescence microscopy, electron microscopy, iclem, life science microscope, scanning electron microscope, correlative light and electron microscopy, clem video

Potential of correlative light and electron microscopy for understanding Diabetes Type 1

Posted by Vera Lanskaya on Feb 19, 2018 11:59:04 AM

Diabetes Type 1, one of the two widely spread forms, is an autoimmune decease, which is caused by destruction of insulin-producing beta cells in pancreas. This type of Diabetes is called insulin-dependent: the body’s immune system attacks the beta cells located in the Islets of Langerhans in the pancreas, which normally maintain the blood sugar levels by producing the necessary amount of insulin. When the islets do not release the insulin, the amount of glucose in the blood builds up. This results in cells suffering and dying from the lack of glucose and high blood sugar levels, which makes multiple organs collapse and lead to coma and death.

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Topics: correlative microscopy, life sciences, SECOM, clem, correlative light electron microscope

An inside look at the department of Imaging Physics, TU Delft: The breeding ground for innovations in iCLEM

Posted by Delmic on Sep 28, 2017 4:29:42 PM

Understanding the relationship between structure and function in biology requires continuous developments in the field of microscopy. While electron microscopes and fluorescence microscopes have been go-to techniques for studying organic samples at a high resolution, individually they fall short in offering the exhaustive data needed for truly in-depth life science research.

In 2011, the Charged Particle Optics group at TU Delft completed the development of the SECOM. This system integrates a light and electron microscope, thus combining the labelling capabilities of fluorescence microscopy with the high-resolution nanoscale data obtained from electron microscopy. Six years later, the department of Imaging Physics houses no less than five SECOM systems.

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Topics: correlative microscopy, life sciences, microscopy, SECOM

Thoughts on the various applications, techniques, and complications to be discovered in the fascinating fields of both cathodoluminescence and correlative light and electron microscopy.

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