--- title: Delmic Microscopy Blog | Marit Smeets description: This blog addresses the various applications and techniques to be discovered in the fields of cathodoluminescence and correlative light and electron microscopy. --- [![](https://blog.delmic.com/hs-fs/hubfs/Friday%20ZEISS.png?width=620&name=Friday%20ZEISS.png) ](https://blog.delmic.com/5-key-challenges-in-cryo-fib-targeting-and-how-to-overcome-them) ###### [cryo electron microscopy](https://blog.delmic.com/topic/cryo-electron-microscopy) ## [5 Key Challenges in Cryo-FIB Targeting — and How to Overcome Them](https://blog.delmic.com/5-key-challenges-in-cryo-fib-targeting-and-how-to-overcome-them) Achieving high-accuracy targeting in cryo-focused ion beam (cryo-FIB) workflows is essential for generating high-quality lamellae for cryo-electron tomography (cryo-ET). But accuracy doesn’t come... [![](https://blog.delmic.com/hs-fs/hubfs/C.%20elegans-1.png?width=380&name=C.%20elegans-1.png) ](https://blog.delmic.com/introducing-meteor-2.0) ###### [life sciences](https://blog.delmic.com/topic/life-sciences) ##### [See More with Less: Discover the Power of METEOR 2.0](https://blog.delmic.com/introducing-meteor-2.0) [![](https://blog.delmic.com/hs-fs/hubfs/MAX_Composite_post-mill-3d.jpg?width=380&name=MAX_Composite_post-mill-3d.jpg) ](https://blog.delmic.com/the-case-for-sensitivity-in-integrated-fluorescence-microscopes) ###### [cryo electron microscopy](https://blog.delmic.com/topic/cryo-electron-microscopy) ##### [The case for sensitivity in integrated fluorescence microscopes](https://blog.delmic.com/the-case-for-sensitivity-in-integrated-fluorescence-microscopes) [![](https://blog.delmic.com/hs-fs/hubfs/Website/Blog/Sample%20Prep%20Cryo-ET_Website.png?width=380&name=Sample%20Prep%20Cryo-ET_Website.png) ](https://blog.delmic.com/how-to-streamline-the-cryo-et-workflow-and-get-more-useful-biological-insights) ###### [life sciences](https://blog.delmic.com/topic/life-sciences) ##### [How to streamline the cryo-ET workflow and get more useful biological insights](https://blog.delmic.com/how-to-streamline-the-cryo-et-workflow-and-get-more-useful-biological-insights) ## Must read - ## 1 [How electron microscopy shapes the way we think, according to 6 prominent scientists](https://blog.delmic.com/how-electron-microscopy-shapes-the-way-we-think) - ## 2 [Cryo-ET imaging of SARS-CoV-2 replication organelles](https://blog.delmic.com/cryo-et-imaging-of-sars-cov-2-replication-organelles) - ## 3 [Will lead-free Perovskite solar cells lead the future?](https://blog.delmic.com/to-lead-or-not-to-lead-will-lead-free-perovskite-solar-cells-lead-the-future) - ## 4 [See More with Less: Discover the Power of METEOR 2.0](https://blog.delmic.com/introducing-meteor-2.0) - ## 5 [The case for sensitivity in integrated fluorescence microscopes](https://blog.delmic.com/the-case-for-sensitivity-in-integrated-fluorescence-microscopes) [![](https://blog.delmic.com/hs-fs/hubfs/Website/Blog/2021_HeLA%20Yeast%20Blogpost_Website%20(1).png?width=380&name=2021_HeLA%20Yeast%20Blogpost_Website%20(1).png) ](https://blog.delmic.com/applications-of-an-integrated-cryogenic-fluorescent-light-microscope) ###### [life sciences](https://blog.delmic.com/topic/life-sciences) ##### [Applications of an integrated cryogenic fluorescent light microscope](https://blog.delmic.com/applications-of-an-integrated-cryogenic-fluorescent-light-microscope) Do you know how an integrated cryogenic fluorescent light microscope can streamline the cryo-ET workflow for targeted lamella milling of HeLa and yeast cells? ... [![](https://blog.delmic.com/hs-fs/hubfs/Website/Blog/CRYO_Ice%20Contamination_Website_Labeled.png?width=380&name=CRYO_Ice%20Contamination_Website_Labeled.png) ](https://blog.delmic.com/preventing-ice-contamination-in-single-particle-cryo-electron-microscopy) ###### [life sciences](https://blog.delmic.com/topic/life-sciences) ##### [Preventing ice contamination in single-particle electron microscopy](https://blog.delmic.com/preventing-ice-contamination-in-single-particle-cryo-electron-microscopy) There is an increasing number of institutes that are starting to employ cryo-EM. However, many challenges are involved and specimen preparation is still a ... [![](https://blog.delmic.com/hs-fs/hubfs/Website/Blog/METEOR_MillingWorkflow_Blogpost.png?width=380&name=METEOR_MillingWorkflow_Blogpost.png) ](https://blog.delmic.com/focused-ion-beam-sample-preparation-for-cryo-electron-tomography) ###### [life sciences](https://blog.delmic.com/topic/life-sciences) ##### [Focused ion beam sample preparation for cryo-electron tomography](https://blog.delmic.com/focused-ion-beam-sample-preparation-for-cryo-electron-tomography) Cryo-electron tomography (cryo-ET) is an extremely powerful technique that allows studies of the cellular landscape at high resolution in a near-native state. ... ### Receive the latest updates in your mail [![](https://blog.delmic.com/hs-fs/hubfs/Website/Blog/20201021meteorblog.png?width=380&name=20201021meteorblog.png) ](https://blog.delmic.com/meteor-an-integrated-top-down-cryo-clem-imaging-system) ###### [cryo electron microscopy](https://blog.delmic.com/topic/cryo-electron-microscopy) ##### [METEOR: an integrated top down cryo-CLEM imaging system](https://blog.delmic.com/meteor-an-integrated-top-down-cryo-clem-imaging-system) In our previous blogposts we discussed different applications of cryogenic electron tomography (cryo-ET) and how an integrated fluorescent light microscope ... [![](https://blog.delmic.com/hs-fs/hubfs/Website/Blog/20200806%20cryo%20blog%20august.png?width=380&name=20200806%20cryo%20blog%20august.png) ](https://blog.delmic.com/recent-advances-in-automated-lamellae-milling) ###### [cryo electron microscopy](https://blog.delmic.com/topic/cryo-electron-microscopy) ##### [Recent advances in automated lamellae milling](https://blog.delmic.com/recent-advances-in-automated-lamellae-milling) Cryo-electron tomography (cryo-ET) is an emerging technique that allows scientists to determine the structure of biological complexes within their cellular ... [![](https://blog.delmic.com/hs-fs/hubfs/Website/Blog/20200721_BlogpostJuly_CryoLiftout-01.png?width=380&name=20200721_BlogpostJuly_CryoLiftout-01.png) ](https://blog.delmic.com/how-can-integrated-flm-simplify-the-cryo-fib-lift-out-technique) ###### [cryo electron microscopy](https://blog.delmic.com/topic/cryo-electron-microscopy) ##### [How can integrated FLM simplify the cryo-FIB lift-out technique?](https://blog.delmic.com/how-can-integrated-flm-simplify-the-cryo-fib-lift-out-technique) Cryo-electron tomography (ET) in combination with cryo-focused ion beam (FIB) milling allows the study of biological structures in near native conditions at a ... [![](https://blog.delmic.com/hs-fs/hubfs/Website/Blog/20200529-cryo-blog.png?width=380&name=20200529-cryo-blog.png) ](https://blog.delmic.com/how-can-an-optimized-cryo-et-workflow-benefit-research-research-of-viral-infection) ###### [life sciences](https://blog.delmic.com/topic/life-sciences) ##### [How can an optimized cryo-ET workflow benefit the research of viral infection?](https://blog.delmic.com/how-can-an-optimized-cryo-et-workflow-benefit-research-research-of-viral-infection) Viruses are microscopic infectious agents that are not able to reproduce outside of their hosts. We associate viruses with a variety of diseases, ranging from ... [![](https://blog.delmic.com/hs-fs/hubfs/Website/Blog/20200331%20Cryo%20Blog%20Post.png?width=380&name=20200331%20Cryo%20Blog%20Post.png) ](https://blog.delmic.com/using-integrated-fluorescence-light-microscopy-to-improve-the-cryo-electron-tomography-workflow) ###### [cryo electron microscopy](https://blog.delmic.com/topic/cryo-electron-microscopy) ##### [Using integrated fluorescence light microscopy to improve the cryo-electron tomography workflow](https://blog.delmic.com/using-integrated-fluorescence-light-microscopy-to-improve-the-cryo-electron-tomography-workflow) Cryogenic electron tomography (cryo-ET) is an imaging technique that uses a cryo Transmission Electron Microscope (cryo-TEM) to acquire high-resolution 3D ...