---
title: "Cryo R&D story, episode 4: Keeping your cryo samples actively cooled in our era-defining cryo-CLEM system"
description: The fourth episode of the Delmic Cryo R&D story is now released!  Stay tuned with the behind-the-scene Delmic Cryo R&D story video series
image: https://blog.delmic.com/hubfs/Website/News/2021_ENZEL_UnlockingPowerCryo-ET_Ep4_Website.png
---

###### [cryo electron microscopy](https://blog.delmic.com/news/topic/cryo-electron-microscopy), [cryo-electron tomography](https://blog.delmic.com/news/topic/cryo-electron-tomography) • 1

# Cryo R&D story, episode 4: Keeping your cryo samples actively cooled in our era-defining cryo-CLEM system

[Jingyue Liu September 28, 2021](https://blog.delmic.com/news/author/jingyue-liu)

![](https://blog.delmic.com/hs-fs/hubfs/Website/News/2021_ENZEL_UnlockingPowerCryo-ET_Ep4_Website.png?width=1080&name=2021_ENZEL_UnlockingPowerCryo-ET_Ep4_Website.png)

Check out the fourth episode of the Delmic Cryo R&D stories! Watch the story to learn about our unique approach innovated to keep your cryo samples actively cooled in our era-defining integrated cryo-CLEM system.

In the last episode, our Mechanical Designer Keith Baelz talked about the new transfer mechanism that redefines the traditional sample transfer workflow, where there is always a significant risk of sample damage. Apart from ensuring your cryo-sample stay vitrified in the transfer processes, our development team also came up with a smart design of a unique cooler being placed in the era-defining integrated cyro-CLEM system. With this micro cooler the cryo sample can be actively cooled while the electron, ion and photon beams are working simultaneously.

In the fourth episode of the R&D series "Unlocking the power of cryo-ET", our Application Specialist Caspar Jonker introduced how this micro cooler is designed and placed in the FIB/SEM chamber of our fully automated cryo-CLEM system that is being developed in the ENZEL project. Watch this story now!

 

Subscribe to our newsletter below to receive the following episodes of this video series in your email.

![https://request.delmic.com/hubfs/Website%20Content%20Offers/Publications/publications_resourcelibrary__CRYO_380x215%20copy%203.png](https://blog.delmic.com/hs-fs/hubfs/Website%20Content%20Offers/Publications/publications_resourcelibrary__CRYO_380x215%20copy%203.png?width=227&name=publications_resourcelibrary__CRYO_380x215%20copy%203.png)

###### R&D story series

## Subscribe to stay tuned with our cryo-EM R&D stories

[![Subscribe](https://no-cache.hubspot.com/cta/default/1767973/a19d7d3f-f006-4b32-a3f1-a87354dba80f.png)](https://cta-redirect.hubspot.com/cta/redirect/1767973/a19d7d3f-f006-4b32-a3f1-a87354dba80f)

#### Jingyue Liu

[![](https://blog.delmic.com/hs-fs/hubfs/Website%20Content%20Offers/Webinars/Webinar%20Thumbnails/2024_In-Tissue-Cryo-ET_Webinars_Resources_270px.png?width=380&name=2024_In-Tissue-Cryo-ET_Webinars_Resources_270px.png) ](https://blog.delmic.com/news/delmics-first-cryo-et-online-symposium) [###### life sciences

## DELMIC's Cryo-ET Online Symposium 2025

DELMIC Cryo-ET Online Symposium 2025 brings to you 7 expert speakers from the cryo-ET field. They will share with the audience their latest advanced cryo-ET ...

](https://blog.delmic.com/news/delmics-first-cryo-et-online-symposium)

[![](https://blog.delmic.com/hs-fs/hubfs/Jerez-TV-Rockefeller-University-02-1.jpg?width=380&name=Jerez-TV-Rockefeller-University-02-1.jpg) ](https://blog.delmic.com/news/delmic-showcases-user-friendly-and-contamination-minimizing-cryo-et-solutions-at-rockefeller-university) [###### life sciences

## Delmic showcases user-friendly and contamination minimizing cryo-ET solutions at Rockefeller University

Delmic celebrates a successful demo workshop dedicated to our cryo-ET solutions METEOR and CERES Ice Shield held at Rockefeller University in the United ...

](https://blog.delmic.com/news/delmic-showcases-user-friendly-and-contamination-minimizing-cryo-et-solutions-at-rockefeller-university)

[![](https://blog.delmic.com/hs-fs/hubfs/2022_Delmic_M%26M%20Meeting%20Promo_Website.png?width=380&name=2022_Delmic_M%26M%20Meeting%20Promo_Website.png) ](https://blog.delmic.com/news/join-delmic-at-microscopy-microanalysis-mm-meeting-2022) [###### cathodoluminescence

## Join Delmic at Microscopy & MicroAnalysis (M&M) Meeting 2022

It’s official, Delmic is going to M&M 2022 in Portland, Oregon! You’ll find us at the biggest microscopy event of the year. We’ll be presenting our METEOR, ...

](https://blog.delmic.com/news/join-delmic-at-microscopy-microanalysis-mm-meeting-2022)