α-Synuclein (α-Syn) aggregation is a hallmark of several neurodegenerative diseases such as multiple systems atrophy (MSA) and Parkinson’s Disease (PD), but the molecular architecture of α-Syn inclusions still remains unclear. In recent years several hypotheses were posed on the exact functioning. To test these ideas, the authors of the article "In situ architecture of neuronal α-Synuclein inclusions" employed cryo-electron tomography (cryo-ET) to reveal the molecular architecture of α-Syn aggregates at high resolution within neurons.

In this Journal Club, our hosts Dr. Caspar Jonker and Marit Smeets will discuss α-Syn aggregates, which consist of cellular organelles and α-Syn fibrils as shown in the article. However, α-Syn does not link organelles to each other and fibrils do not interact with membranes directly. Would you like to know more about how we can use cryo-ET to reveal the molecular architecture of neuronal α-Synuclein inclusions? Register now and don't forget to join us live!

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