--- title: New paper about the benefits of super-resolution correlative microscopy description: A newly published paper in the Journal of Stuctural Biology attests to the value of super-resolution CLEM using Delmic's SECOM Super-Resolution system. image: https://blog.delmic.com/hubfs/Website_pictures/News/secom-sr-news.jpg --- ###### [life sciences](https://blog.delmic.com/news/topic/life-sciences) • 1 # New paper about the benefits of super-resolution correlative microscopy [Kaitlin van Baarle June 13, 2017](https://blog.delmic.com/news/author/kaitlin-van-baarle) ![super-resolution correlative microscopy](https://blog.delmic.com/hs-fs/hubfs/Website_pictures/News/secom-sr-news.jpg?width=1080&name=secom-sr-news.jpg) In recent decades, several advancements have been made in microscopic imaging in the life sciences. One of the most pivotal innovations is super-resolution light microscopy, which is able to surpass the diffraction limit of light to create images of organic samples at an extremely high resolution. [A newly published paper in the Journal of Stuctural Biology](http://www.sciencedirect.com/science/article/pii/S104784771730093X) attests to the value of super-resolution CLEM with highly detailed images of fluorescent proteins and cellular structures using Delmic's [SECOM Super-Resolution](https://www.delmic.com/secom-super-resolution) system. According to the authors, a major advantage of an integrated CLEM system is the ability to create an image of a sample with two microscopes simultaneously, which reduces unwanted changes to the sample in between measurements. Although CLEM presents its own unique challenges in terms of sample preparation, the authors demonstrate a workable method using specific fluorescent probes that can be imaged under both EM and FM.  The authors also illustrate the benefits of using a super-resolution light microscope, which is able to localize regions of interest in a much more precise manner. Images show that not only is the lipid dygliceride (DAG) located in a certain region of the cell, but it can be identified specifically within Golgi stacks, endoplasmic reticulum, and a putative autophagosome. The entire paper can be read [here](http://www.sciencedirect.com/science/article/pii/S104784771730093X).  If you would like to learn more about Delmic's SECOM Super-Resolution system, we invite you to download the brochure:  #### Kaitlin van Baarle [![](https://blog.delmic.com/hs-fs/hubfs/HER2--1.png?width=380&name=HER2--1.png) ](https://blog.delmic.com/news/delmics-vem-webinars-2026-nanoscale-3d-cellular-atlases) [###### life sciences ## Delmic vEM Webinars Session 2026: Nanoscale 3D Cellular Atlases Nanoscale 3D Cellular Atlases: Novel Insights into Organelle Interactions Illuminating Cellular Mechanisms ](https://blog.delmic.com/news/delmics-vem-webinars-2026-nanoscale-3d-cellular-atlases) [![](https://blog.delmic.com/hs-fs/hubfs/Website%20Content%20Offers/Webinars/Webinar%20Thumbnails/2024_In-Tissue-Cryo-ET_Webinars_Resources_270px.png?width=380&name=2024_In-Tissue-Cryo-ET_Webinars_Resources_270px.png) ](https://blog.delmic.com/news/delmics-first-cryo-et-online-symposium) [###### life sciences ## DELMIC's Cryo-ET Online Symposium 2025 DELMIC Cryo-ET Online Symposium 2025 brings to you 7 expert speakers from the cryo-ET field. They will share with the audience their latest advanced cryo-ET ... ](https://blog.delmic.com/news/delmics-first-cryo-et-online-symposium) [![](https://blog.delmic.com/hs-fs/hubfs/Jerez-TV-Rockefeller-University-02-1.jpg?width=380&name=Jerez-TV-Rockefeller-University-02-1.jpg) ](https://blog.delmic.com/news/delmic-showcases-user-friendly-and-contamination-minimizing-cryo-et-solutions-at-rockefeller-university) [###### life sciences ## Delmic showcases user-friendly and contamination minimizing cryo-ET solutions at Rockefeller University Delmic celebrates a successful demo workshop dedicated to our cryo-ET solutions METEOR and CERES Ice Shield held at Rockefeller University in the United ... ](https://blog.delmic.com/news/delmic-showcases-user-friendly-and-contamination-minimizing-cryo-et-solutions-at-rockefeller-university)