Transferring the sample, acquiring data and overlaying the images can be extremely laborious. Correlative light and electron microscopy (also known as CLEM) is an imaging technique that eliminates these challenges by combining light microscope with a scanning electron microscope, making the process of image acquisition and overlaying seamless and user-friendly. 

What about the sample preparation? If you are interested to know everything about it as well, make sure to download our white paper on sample preparation specifically for this imaging technique.