All articles written by Caspar Jonker

Picture of Caspar Jonker

Caspar Jonker

cryo electron microscopy

Subtomogram averaging in the cryo-ET workflow

Cryo-electron tomography (cryo-ET) allows the 3D visualization of a small volume of a vitreous biological sample with nanometer resolution. Protein complexes that reside in the tomogram can be studied in even greater detail with subtomogram averaging. Subtomogram averaging is the process of aligning multiple 3D reconstructions of identical protein complexes and averaging them.