--- title: Delmic Microscopy Blog | cryo electron microscopy description: cryo electron microscopy | This blog addresses the various applications and techniques to be discovered in the fields of cathodoluminescence and correlative light and electron microscopy. --- [![](https://blog.delmic.com/hs-fs/hubfs/Friday%20ZEISS.png?width=620&name=Friday%20ZEISS.png) ](https://blog.delmic.com/5-key-challenges-in-cryo-fib-targeting-and-how-to-overcome-them) ###### [cryo electron microscopy](https://blog.delmic.com/topic/cryo-electron-microscopy) ## [5 Key Challenges in Cryo-FIB Targeting — and How to Overcome Them](https://blog.delmic.com/5-key-challenges-in-cryo-fib-targeting-and-how-to-overcome-them) Achieving high-accuracy targeting in cryo-focused ion beam (cryo-FIB) workflows is essential for generating high-quality lamellae for cryo-electron tomography (cryo-ET). But accuracy doesn’t come... [![](https://blog.delmic.com/hs-fs/hubfs/MAX_Composite_post-mill-3d.jpg?width=380&name=MAX_Composite_post-mill-3d.jpg) ](https://blog.delmic.com/the-case-for-sensitivity-in-integrated-fluorescence-microscopes) ###### [cryo electron microscopy](https://blog.delmic.com/topic/cryo-electron-microscopy) ##### [The case for sensitivity in integrated fluorescence microscopes](https://blog.delmic.com/the-case-for-sensitivity-in-integrated-fluorescence-microscopes) [![](https://blog.delmic.com/hs-fs/hubfs/cryo%20plasma%20fibsem.png?width=380&name=cryo%20plasma%20fibsem.png) ](https://blog.delmic.com/cryo-plasma-fib-sem-volume-imaging) ###### [life sciences](https://blog.delmic.com/topic/life-sciences) ##### [Exploring cryo-plasma FIB/SEM volume imaging for biological specimens](https://blog.delmic.com/cryo-plasma-fib-sem-volume-imaging) [![](https://blog.delmic.com/hs-fs/hubfs/Cryo%20et%20with%20FIB.webp?width=380&name=Cryo%20et%20with%20FIB.webp) ](https://blog.delmic.com/reduce-contamination-in-cryo-et-with-advanced-cryo-fib) ###### [life sciences](https://blog.delmic.com/topic/life-sciences) ##### [How to reduce contamination in Cryo-ET with advanced Cryo-FIB techniques](https://blog.delmic.com/reduce-contamination-in-cryo-et-with-advanced-cryo-fib) ## Must read - ## 1 [How electron microscopy shapes the way we think, according to 6 prominent scientists](https://blog.delmic.com/how-electron-microscopy-shapes-the-way-we-think) - ## 2 [Cryo-ET imaging of SARS-CoV-2 replication organelles](https://blog.delmic.com/cryo-et-imaging-of-sars-cov-2-replication-organelles) - ## 3 [Will lead-free Perovskite solar cells lead the future?](https://blog.delmic.com/to-lead-or-not-to-lead-will-lead-free-perovskite-solar-cells-lead-the-future) - ## 4 [See More with Less: Discover the Power of METEOR 2.0](https://blog.delmic.com/introducing-meteor-2.0) - ## 5 [The case for sensitivity in integrated fluorescence microscopes](https://blog.delmic.com/the-case-for-sensitivity-in-integrated-fluorescence-microscopes) [![](https://blog.delmic.com/hs-fs/hubfs/Website/Blog/2024_Cryo_Blog-Content_Ice-Contamination-Challenges_Header.jpg?width=380&name=2024_Cryo_Blog-Content_Ice-Contamination-Challenges_Header.jpg) ](https://blog.delmic.com/addressing-ice-contamination-challenges-in-cryo-et-workflow) ###### [life sciences](https://blog.delmic.com/topic/life-sciences) ##### [Addressing ice contamination challenges in the Cryo-ET workflow](https://blog.delmic.com/addressing-ice-contamination-challenges-in-cryo-et-workflow) [![](https://blog.delmic.com/hs-fs/hubfs/Website/Blog/2023_Cryo_CryoCLEM-Advantages_Header.jpg?width=380&name=2023_Cryo_CryoCLEM-Advantages_Header.jpg) ](https://blog.delmic.com/advantages-of-cryo-correlative-light-and-electron-microscopy) ###### [life sciences](https://blog.delmic.com/topic/life-sciences) ##### [What Are The Advantages Of Cryo-Correlative Light And Electron Microscopy?](https://blog.delmic.com/advantages-of-cryo-correlative-light-and-electron-microscopy) Researchers in life sciences are using a combination of cryo-electron microscopy and light microscopy to gain new insights into their research. In this blog ... [![](https://blog.delmic.com/hs-fs/hubfs/Website/Blog/2023_Cryo_Accelerate%20Drug%20Discovery_Header.png?width=380&name=2023_Cryo_Accelerate%20Drug%20Discovery_Header.png) ](https://blog.delmic.com/cryo-electron-microscopy-for-drug-discovery) ###### [life sciences](https://blog.delmic.com/topic/life-sciences) ##### [How Cryo-Electron Microscopy Can Accelerate Drug Discovery](https://blog.delmic.com/cryo-electron-microscopy-for-drug-discovery) Cryo-EM is a powerful tool in structural biology, allowing researchers to obtain high-resolution reconstructions of macromolecular structures. Here, we will ... ### Receive the latest updates in your mail [![](https://blog.delmic.com/hs-fs/hubfs/Website/Blog/2023_Cryo_Public%20Image%20Archive_Header%20v2.gif?width=380&name=2023_Cryo_Public%20Image%20Archive_Header%20v2.gif) ](https://blog.delmic.com/public-image-archives-for-3d-electron-microscopy) ###### [life sciences](https://blog.delmic.com/topic/life-sciences) ##### [Public Image Archives: The Power of Data Sharing for 3D EM](https://blog.delmic.com/public-image-archives-for-3d-electron-microscopy) Although most scientific articles impose copyright regulations to prevent sharing and using their 3D electron microscopy (EM) data, public image archives ... [![](https://blog.delmic.com/hs-fs/hubfs/Website/Blog/2023_Cryo_Cryo-FIB%20Lift-out_HeaderV2.png?width=380&name=2023_Cryo_Cryo-FIB%20Lift-out_HeaderV2.png) ](https://blog.delmic.com/cryo-fib-lift-out-enabling-cryo-et-imaging-for-tissues) ###### [life sciences](https://blog.delmic.com/topic/life-sciences) ##### [Cryo-FIB Lift-Out: Enabling Cryo-ET Imaging for Tissues](https://blog.delmic.com/cryo-fib-lift-out-enabling-cryo-et-imaging-for-tissues) As the boundaries of cryo-electron tomography are continuously being pushed, there are major advancements in the development of cryo-FIB lift-out techniques, ... [![](https://blog.delmic.com/hs-fs/hubfs/Website/Blog/2023_Cryo_Cryo-EM%20vs%20Cryo-ET_Website.png?width=380&name=2023_Cryo_Cryo-EM%20vs%20Cryo-ET_Website.png) ](https://blog.delmic.com/what-is-the-difference-between-cryo-em-and-cryo-et) ###### [life sciences](https://blog.delmic.com/topic/life-sciences) ##### [What is the difference between cryo-EM and cryo-ET?](https://blog.delmic.com/what-is-the-difference-between-cryo-em-and-cryo-et) Advancements in technology increased the popularity of cryo-electron microscopy (cryo-EM) techniques such as cryo-electron tomography (cryo-ET) and ... [![](https://blog.delmic.com/hs-fs/hubfs/Website/Blog/2023_Cryo_Parkinsons%20disease%20Cryo-EM_Header.png?width=380&name=2023_Cryo_Parkinsons%20disease%20Cryo-EM_Header.png) ](https://blog.delmic.com/a-molecular-view-on-parkinsons-disease-using-cryo-em) ###### [life sciences](https://blog.delmic.com/topic/life-sciences) ##### [A molecular view on Parkinson’s disease using cryo-EM](https://blog.delmic.com/a-molecular-view-on-parkinsons-disease-using-cryo-em) Advances in cryo electron microscopy made it possible to shed light on the molecular pathology of Parkinson's disease. Here, we discuss recent exciting ... [![](https://blog.delmic.com/hs-fs/hubfs/Website/Blog/2022_Cryo_Crosstalk%20Blogpost_Website.png?width=380&name=2022_Cryo_Crosstalk%20Blogpost_Website.png) ](https://blog.delmic.com/overcoming-artifacts-in-cryogenic-fluorescence-microscopy) ###### [life sciences](https://blog.delmic.com/topic/life-sciences) ##### [Overcoming artifacts in cryogenic fluorescence microscopy](https://blog.delmic.com/overcoming-artifacts-in-cryogenic-fluorescence-microscopy) Cryogenic fluorescence microscopy (cryo-FLM) combined with scanning electron microscopy (SEM) makes the process of lamella milling in the cryo-electron ... - [1](https://blog.delmic.com) - [2](https://blog.delmic.com/topic/cryo-electron-microscopy/page/2) - [3](https://blog.delmic.com/topic/cryo-electron-microscopy/page/3) - [![→](https://blog.delmic.com/hubfs/system/icons/arrow-right-black.svg)](https://blog.delmic.com/topic/cryo-electron-microscopy/page/2)