By visualizing membrane ultrastructure directly in the cells, researchers can better understand their diversity, dynamics, and role. In this blog post, we highlight a beautiful example where researchers used cryo-CLEM to reveal the ultrastructural changes in the autophagosome membrane during its biogenesis.
Cryogenic fluorescence microscopy (cryo-FLM) combined with scanning electron microscopy (SEM) makes the process of lamella milling in the cryo-electron ...
Understanding how different materials work and knowing their properties has been a keystone in human progress. In our efforts to build an environmentally ...
Sample milling is a crucial step in the Cryo-ET workflow. Unfortunately, this step poses yet another occasion for ice contamination to derail efforts to obtain ...
With more than 90 years of development, electron microscopy is now a mature, well-established technique applied in many life science fields, such as pathology, ...
There are more than 150 known musculoskeletal conditions (1), many of which affect specifically skeletal muscles and can lead to lifelong disabilities or even ...
Cryo-EM research helps us understand how the world works on a microscale. Often these insights have a great impact on our lives, for example, the understanding ...
Sample transfer is definitely not the most spectacular part of the cryo-ET workflow. And yet, it is one of the most problematic steps, disturbing many ...
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