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Sample milling is a crucial step in the Cryo-ET workflow. Unfortunately, this step poses yet another occasion for ice contamination to derail efforts to obtain ...

With more than 90 years of development, electron microscopy is now a mature, well-established technique applied in many life science fields, such as pathology, ...

There are more than 150 known musculoskeletal conditions (1), many of which affect specifically skeletal muscles and can lead to lifelong disabilities or even ...

Cryo-EM research helps us understand how the world works on a microscale. Often these insights have a great impact on our lives, for example, the understanding ...

Geochronology plays a central role in geosciences and all historical aspects of the Earth sciences. Over the years, it has become an essential scientific field ...

Sample transfer is definitely not the most spectacular part of the cryo-ET workflow. And yet, it is one of the most problematic steps, disturbing many ...

Cathodoluminescence (CL) is the process of light emission from a material as a result of excitation by electrons. Imaging CL can therefore enable us to study ...

Cryo-electron tomography (cryo-ET) is an extremely powerful technique that allows studies of the cellular landscape at high resolution in a near-native state.

Do you know how an integrated cryogenic fluorescent light microscope can streamline the cryo-ET workflow for targeted lamella milling of HeLa and yeast cells? ...

The great potential of CLEM lies in the combination of two modalities: multi-colour labelling together with high-resolution contextual information from the ...

There is an increasing number of institutes that are starting to employ cryo-EM. However, many challenges are involved and specimen preparation is still a ...

The staining of specimens is a crucial step of biological electron microscopy workflows. Choosing a staining protocol tailored to the demands of a project can ...