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Cryo-EM research helps us understand how the world works on a microscale. Often these insights have a great impact on our lives, for example, the understanding of how different drugs and drug candidates interact with targeted proteins facilitates the design of new medication [1, 2]. However, getting powerful high-quality data using cryo-EM is extremely difficult.
Single particle cryo-electron microscopy (cryo-EM) is a powerful method to determine near-atomic structures of macromolecular complexes. In recent years this ...
The cryo-ET workflow is labour intensive and requires specialized equipment and expertise. One of the biggest hurdles in the current Cryo-ET workflow is ...
METEOR, our integrated top down fluorescence light microscope (FLM) increases lamella sample preparation for cryo-electron tomography imaging (cryo-ET). This ...
In our previous blogposts we discussed different applications of cryogenic electron tomography (cryo-ET) and how an integrated fluorescent light microscope ...
Cryo-electron tomography (cryo-ET) allows the 3D visualization of a small volume of a vitreous biological sample with nanometer resolution. Protein complexes ...
Cryo-electron tomography (cryo-ET) is an emerging technique that allows scientists to determine the structure of biological complexes within their cellular ...
Cryo-electron tomography (ET) in combination with cryo-focused ion beam (FIB) milling allows the study of biological structures in near native conditions at a ...
Eukaryotic cells contain a complex network of membrane-bound organelles where specialized processes of the cell take place.
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