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The cryo-ET workflow is labour intensive and requires specialized equipment and expertise. One of the biggest hurdles in the current Cryo-ET workflow is avoiding ice contamination of the vitreous sample. However, because of the many sample handling steps in the current workflow, ice contamination is nearly impossible to avoid completely. Therefore, most cryo-ET users report low success rates and low throughputs.
Cryo-electron tomography (cryo-ET) is an emerging technique that allows scientists to determine the structure of biological complexes within their cellular ...
Cryo-electron tomography (ET) in combination with cryo-focused ion beam (FIB) milling allows the study of biological structures in near native conditions at a ...
Eukaryotic cells contain a complex network of membrane-bound organelles where specialized processes of the cell take place.
Viruses are microscopic infectious agents that are not able to reproduce outside of their hosts. We associate viruses with a variety of diseases, ranging from ...
In cryogenic electron microscopy (cryo-EM) a sample is immobilized by rapid freezing in a process called vitrification.
Cryogenic electron tomography (cryo-ET) is an imaging technique that uses a cryo Transmission Electron Microscope (cryo-TEM) to acquire high-resolution 3D ...
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