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life sciences
Uncovering 3D molecular organization and interactions between muscle proteins using in situ cryo-electron tomography

There are more than 150 known musculoskeletal conditions (1), many of which affect specifically skeletal muscles and can lead to lifelong disabilities or even ...

life sciences
How to keep the cryo-EM sample clean and safe during sample preparation process?

Cryo-EM research helps us understand how the world works on a microscale. Often these insights have a great impact on our lives, for example, the understanding ...

life sciences
How to minimize ice formation during sample transfer in cryo-ET?

Sample transfer is definitely not the most spectacular part of the cryo-ET workflow. And yet, it is one of the most problematic steps, disturbing many ...

life sciences
How to streamline the cryo-ET workflow and get more useful biological insights

Cryo-electron tomography (cryo-ET) is an extremely powerful technique that allows studies of the cellular landscape at high resolution in a near-native state.

life sciences
Applications of an integrated cryogenic fluorescent light microscope

Do you know how an integrated cryogenic fluorescent light microscope can streamline the cryo-ET workflow for targeted lamella milling of HeLa and yeast cells? ...

life sciences
Preventing ice contamination in single-particle electron microscopy

There is an increasing number of institutes that are starting to employ cryo-EM. However, many challenges are involved and specimen preparation is still a ...

life sciences
Preventing ice contamination in the cryo-ET workflow

One of the biggest hurdles in the current cryo-ET workflow is avoiding ice contamination of the vitreous sample, which is difficult to avoid due to the many ...

cryo electron microscopy
Preparing cryo-lamellae with the guidance of METEOR

METEOR, our integrated top down fluorescence light microscope (FLM) increases lamella sample preparation for cryo-electron tomography imaging (cryo-ET). This ...

cryo electron microscopy
METEOR: an integrated top down cryo-CLEM imaging system

In our previous blogposts we discussed different applications of cryogenic electron tomography (cryo-ET) and how an integrated fluorescent light microscope ...

cryo electron microscopy
Subtomogram averaging in the cryo-ET workflow

Cryo-electron tomography (cryo-ET) allows the 3D visualization of a small volume of a vitreous biological sample with nanometer resolution. Protein complexes ...

cryo electron microscopy
Recent advances in automated lamellae milling

Cryo-electron tomography (cryo-ET) is an emerging technique that allows scientists to determine the structure of biological complexes within their cellular ...

cryo electron microscopy
How can integrated FLM simplify the cryo-FIB lift-out technique?

Cryo-electron tomography (ET) in combination with cryo-focused ion beam (FIB) milling allows the study of biological structures in near native conditions at a ...

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Life science Frame 264(3)

Solutions
  • METEOR
  • FAST-EM
  • CERES Ice Shield
  • CERES Sample Preparation
  • SECOM
Workflows
  • Cryo Electron Tomography
  • High-throughput EM
  • Correlative light EM

Materials analysis Frame 264(3)

Solutions
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  • SPARC Compact
  • JOLT 2.0
  • LAB Cube
Techniques
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Applications
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Insights Frame 264(3)

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Deep dive
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Company Frame 264(3)

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