For decades, electron microscopes have proven to be great tools for resolving structures at a nanometer scale. Electron microscopy (EM) is increasingly being used in large-scale biological projects, either for volume imaging or large area mapping. In both cases, the desire to resolve nanoscale details is combined with the desire to place these observations into a larger context, which can cover a large area or span through a three-dimensional volume. Thanks to increased automation and image processing efforts, these large-scale imaging projects are now feasible. Information from these projects has already proven highly beneficial for a variety of research fields, including developmental and cell biology, neurosciences and pathology [1, 2, 3].
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