Studying microorganisms (or microbes), which are found in the ocean waters, is a fascinating process that can reveal the hidden secrets about ocean chemistry, biology and climate. Marine microorganisms are exceedingly small, diverse in their forms and distributed across the ocean, which makes it so challenging to analyze them.
Still, marine microbiologists are searching for the answers that will help us to understand the ocean’s ecosystem and how it influences us. This is the focus of the research group of Dr. Sten Littman from Max Planck Institute for Marine Microbiology.
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Topics:
correlative microscopy,
life sciences,
SECOM,
marine biology,
customer story
Integrated correlative light and electron microscopy (iCLEM) is a technique, in which both fluorescence imaging and electron imaging can be performed on one instrument without needing to transfer the sample. Correlative microscopy approach is being used worldwide for cancer research, in marine biology, neuroscience, and cell biology. Recently this technique has also been applied in the field of geology to gain an insight into the sedimentary organic matter in geological materials.
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Topics:
correlative microscopy,
Presentation,
Geology,
SECOM,
fluorescence microscopy,
electron microscopy,
iclem,
scanning electron microscope,
correlative light and electron microscopy,
geological materials
Nowadays it has become crucial for life scientists to gain structural and functional data about the sample in order to understand the biological processes happening at the scale of the nanometer. Light or fluorescence microscopy made it possible for the researchers to detect the functional information and image different colors and parts of the cell. It provides the data to understand the dynamics of the cell, however, the diffraction limit of light doesn’t allow distinguishing objects that are smaller than the wavelength of light. That is when the life scientists turn to electron microscopy, which provides the structural information in a high resolution.
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Topics:
correlative microscopy,
SECOM,
video,
clem,
correlative light electron microscope,
microscopy solution,
integrated clem,
fluorescence microscopy,
electron microscopy,
iclem,
life science microscope,
scanning electron microscope,
correlative light and electron microscopy,
clem video
What is a time-resolved cathodoluminescence? How can it be applied in different fields? In the new video Toon Coenen, application specialist at Delmic, gives an explanation of this imaging technique.
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Topics:
cathodoluminescence,
SPARC,
cathodoluminescence sem,
video,
cathodoluminescence video,
time-resolved cathodoluminescence,
optical modules
How can your research benefit from correlative light and electron microscopy? Why is this technique becoming increasingly attractive to many scientists in different fields of research? This is the main focus of the newest video, in which our application specialist Sangeetha Hari explains the main advantages of correlative light and electron microscopy on the SECOM, a unique microscopy solution for life sciences.
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Topics:
correlative microscopy,
SECOM,
video,
clem,
correlative light electron microscope,
microscopy solution,
integrated clem,
fluorescence microscopy,
electron microscopy,
iclem,
life science microscope,
scanning electron microscope,
correlative light and electron microscopy,
clem video
Diabetes Type 1, one of the two widely spread forms, is an autoimmune decease, which is caused by destruction of insulin-producing beta cells in pancreas. This type of Diabetes is called insulin-dependent: the body’s immune system attacks the beta cells located in the Islets of Langerhans in the pancreas, which normally maintain the blood sugar levels by producing the necessary amount of insulin. When the islets do not release the insulin, the amount of glucose in the blood builds up. This results in cells suffering and dying from the lack of glucose and high blood sugar levels, which makes multiple organs collapse and lead to coma and death.
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Topics:
correlative microscopy,
life sciences,
SECOM,
clem,
correlative light electron microscope
In this short video about the SPARC our application specialist Toon Coenen talks about the main three advantages of this cathodoluminescence system. What are the possibilies of the SPARC and why cathodoluminescence is gaining poplarity in various scientific fields? Find out from the video!
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Topics:
cathodoluminescence,
SPARC,
cathodoluminescence sem,
video,
cathodoluminescence video
Understanding the relationship between structure and function in biology requires continuous developments in the field of microscopy. While electron microscopes and fluorescence microscopes have been go-to techniques for studying organic samples at a high resolution, individually they fall short in offering the exhaustive data needed for truly in-depth life science research.
In 2011, the Charged Particle Optics group at TU Delft completed the development of the SECOM. This system integrates a light and electron microscope, thus combining the labelling capabilities of fluorescence microscopy with the high-resolution nanoscale data obtained from electron microscopy. Six years later, the department of Imaging Physics houses no less than five SECOM systems.
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Topics:
correlative microscopy,
life sciences,
microscopy,
SECOM
In order to make new discoveries in the life sciences, innovations need to be continuously made in microscopy. This way, scientists can take an ever-closer look at phenomena that are happening on a molecular scale.
Fluorescence microscopy is considered a reliable tool for studying organic samples at a high resolution. Nevertheless, the diffraction barrier of light poses the problem of not being able to distinguish objects that are smaller than the wavelength of light. Proteins, for example, can be as small as four nanometers. Even recent developments in light microscopy - such as super-resolution which can resolve objects at a smaller scale - come with the problem of providing no contextual or structural information besides the objects that glow under fluorescence.
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Topics:
correlative microscopy,
life sciences
Scientists of all fields are most certainly familiar with the miniature worlds unearthed by electron microscopy. From the complex structures of viruses to extremely small forensic evidence, the revelations brought about by this technology have led to enormous developments in the scientific world. The wavelength of fast electrons is significantly smaller than that of visible light, creating images that were previously unobtainable with conventional light microscopy. For life scientists in particular, the main advantage of electron microscopy (from here on referred to as EM) is the contrast that the black-and-white high-resolution images reveal, providing essential information on the structure of a cell, organelle, or organic tissue.
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Topics:
correlative microscopy,
life sciences
