Blog

Sapphires grow in environments that attract geologists’ interest. To gain a better understanding of these environments, researchers recently studied sapphire ...

Researchers in life sciences are using a combination of cryo-electron microscopy and light microscopy to gain new insights into their research. In this blog ...

Cathodoluminescence imaging is increasingly used for analyzing a wide range of materials at the nanoscale. But which materials actually emit ...

Volume or 3D electron microscopy (EM) is an upcoming set of techniques that are increasingly used in the field of life sciences. Here, we will explore the main ...

While SiC-powered MOSFETs hold great promise for the field of space electronics, heavy-ion radiation in space causes them damage. Here, we highlight a recent ...

Fluid-rock interactions such as precipitation play a large role in rock deformation. However, the precipitation location is often unknown. Here we highlight ...

Cryo-EM is a powerful tool in structural biology, allowing researchers to obtain high-resolution reconstructions of macromolecular structures. Here, we will ...

Nanoplasmonic materials offer promising applications, but a knowledge gap exists in the physics of plasmonic oscillations in these materials. Here, we discuss ...

Recrystallization events in zircons can affect U-Pb dating. Read in this blog post about a recent investigation of these events using cathodoluminescence ...

Although most scientific articles impose copyright regulations to prevent sharing and using their 3D electron microscopy (EM) data, public image archives ...

Prominent consumer electronics and LED companies, including Apple, are now developing microLED technology. Samsung has already launched microLED TVs. However, ...

As the boundaries of cryo-electron tomography are continuously being pushed, there are major advancements in the development of cryo-FIB lift-out techniques, ...

The analysis of rock samples and minerals in structural geology is now often being done using luminescence techniques. In this blog post, we will highlight the ...

Artificial intelligence (AI) is increasingly used in life sciences, making communication between these fields crucial. Here, we will highlight community ...

The roadmap for the semiconductor industry has shifted from being solely based on Moore's law to incorporating various focus areas, such as 'More than Moore'. ...

Array tomography, which is increasingly used for producing high-resolution 3D images of tissue samples, includes cutting the sample into ultrathin sections. ...

Many of Delmic’s products come with ODEMIS, our open-source microscopy software for image acquisition and analysis. Here, we will highlight the advantages of ...

Electron microscopy (EM) is a powerful tool for life sciences, with the emergence of volume electron microscopy (volume-EM) enabling 3D imaging of samples with ...

Advancements in technology increased the popularity of cryo-electron microscopy (cryo-EM) techniques such as cryo-electron tomography (cryo-ET) and ...

Perovskite solar cells could spur the growth of solar power, but they currently contain lead, which is toxic. Recently, scientists have started to explore ...

We are moving towards a future of open source scientific publications. Apart from publications, software can also be ‘closed’ or ‘open’ source. What does this ...

Advances in cryo electron microscopy made it possible to shed light on the molecular pathology of Parkinson's disease. Here, we discuss recent exciting ...

In this blog post, we discuss the ultrastructure and assembly mechanisms of Rubisco, revealed by cryo-ET. Together with advances in synthetic biology, these ...

When measuring the optical response of silicon nanospheres using cathodoluminescence (CL), researchers found that interference can occur in the spectrum. Here, ...

With advancements in electron microscopy, researchers now aim to build connectomes of increasingly larger brain volumes. In this blog, we discuss exciting ...

Organoids enhance drug screening methods by mimicking in vivo organs. In this blog, we will discuss the exciting possibilities of 3D electron microscopy ...

By visualizing membrane ultrastructure directly in the cells, researchers can better understand their diversity, dynamics, and role. In this blog post, we ...

Manual segmentation of organelles hampers the use of volume electron microscopy in biological research. In this blog, we will discuss a novel approach to ...

There is an increased need for Germanium (Ge), yet little is known about the properties of this scarce element. In this blog, we will discuss a novel paper ...

Using electron microscopy (EM), pathologists can visualize ultrastructural details in biological samples. In this blog, we discuss how recent developments in ...

Intensity mapping using cathodoluminescence (CL) emission is a powerful tool for high-resolution probing of emitters. The CL signal comes from both the UV ...

When choosing the most suitable camera for a cryo-fluorescence system to be applied in cryo-electron tomography (cryo-ET), it is important to consider several ...

The advancement of nanotechnology opened up exciting new possibilities to create nanophotonic structures with nanoscale dimensions. A fundamental understanding ...

Traditionally, scanning electron microscopy (SEM) data management has involved data transfer from a microscope to a hard disc and then loading the data to a ...

Cryogenic fluorescence microscopy (cryo-FLM) combined with scanning electron microscopy (SEM) makes the process of lamella milling in the cryo-electron ...

Understanding how different materials work and knowing their properties has been a keystone in human progress. In our efforts to build an environmentally ...

Sample milling is a crucial step in the Cryo-ET workflow. Unfortunately, this step poses yet another occasion for ice contamination to derail efforts to obtain ...

With more than 90 years of development, electron microscopy is now a mature, well-established technique applied in many life science fields, such as pathology, ...

There are more than 150 known musculoskeletal conditions (1), many of which affect specifically skeletal muscles and can lead to lifelong disabilities or even ...

Cryo-EM research helps us understand how the world works on a microscale. Often these insights have a great impact on our lives, for example, the understanding ...

Geochronology plays a central role in geosciences and all historical aspects of the Earth sciences. Over the years, it has become an essential scientific field ...

Sample transfer is definitely not the most spectacular part of the cryo-ET workflow. And yet, it is one of the most problematic steps, disturbing many ...

Cathodoluminescence (CL) is the process of light emission from a material as a result of excitation by electrons. Imaging CL can therefore enable us to study ...

Cryo-electron tomography (cryo-ET) is an extremely powerful technique that allows studies of the cellular landscape at high resolution in a near-native state.

Do you know how an integrated cryogenic fluorescent light microscope can streamline the cryo-ET workflow for targeted lamella milling of HeLa and yeast cells? ...

The great potential of CLEM lies in the combination of two modalities: multi-colour labelling together with high-resolution contextual information from the ...

There is an increasing number of institutes that are starting to employ cryo-EM. However, many challenges are involved and specimen preparation is still a ...

The staining of specimens is a crucial step of biological electron microscopy workflows. Choosing a staining protocol tailored to the demands of a project can ...

One of the biggest hurdles in the current cryo-ET workflow is avoiding ice contamination of the vitreous sample, which is difficult to avoid due to the many ...

In the past few years, cathodoluminescence (CL) has become more widely used in various fields, including geology, nanophotonics, materials science and even ...

Sample preparation is crucial in electron microscopy (EM), as it influences the final data as much or maybe even more than the quality of the electron ...

Cryo-electron tomography (cryo-ET) is an extremely powerful technique that allows studies of the cellular landscape at high resolution in a near-native state. ...

METEOR, our integrated top down fluorescence light microscope (FLM) increases lamella sample preparation for cryo-electron tomography imaging (cryo-ET). This ...

Parkinson's disease (PD) is a neurodegenerative disease that mainly affects the motor system and its functioning. About one tenth of patients with PD has ...

Nano-anatomy or nanotomy is a term used for large-scale electron microscopy (EM) projects with open access around the globe. This technique, based on large ...

This year was dominated by the outbreak of SARS-CoV-2. Around the world, many researchers are looking into finding a solution for the highly pathogenic ...

As a powerful technique with high spatial resolution, cathodoluminescence (CL) imaging has been applied in many different fields, from geology to nanophotonics ...

Flagella are filamentous protein complexes found on many bacteria and some eukaryotic cells. Imaging techniques such as cryo-electron tomography (cryo-ET), are ...

Understanding the relationship between structure and function in biology relies strongly on imaging. While correlative light and electron microscopy (CLEM) is ...

The increased use of 3DEM in the fields of cell biology and diagnostic pathology is due to the fact that it is one of the most accurate ways to get an overview ...

In our previous blogposts we discussed different applications of cryogenic electron tomography (cryo-ET) and how an integrated fluorescent light microscope ...

Cathodoluminescence imaging is a powerful technique often used to investigate semiconductor materials.

Cryo-electron tomography (cryo-ET) allows the 3D visualization of a small volume of a vitreous biological sample with nanometer resolution. Protein complexes ...

The brain is probably the most complex organ in our body. One of the most fascinating challenges neuroscience faces today is mapping the complete connectivity ...

Cathodoluminescence is commonly used to probe light emission characteristics in semiconductor LED materials.

Cryo-electron tomography (cryo-ET) is an emerging technique that allows scientists to determine the structure of biological complexes within their cellular ...

Cathodoluminescence processes can be divided into two categories: coherent and incoherent CL. But what is the difference between these? In this blog post we ...

In our previous blog post, we discussed how faster and more efficient EM systems can speed up large-scale projects, benefit EM facilities and overall let the ...

Cryo-electron tomography (ET) in combination with cryo-focused ion beam (FIB) milling allows the study of biological structures in near native conditions at a ...

Cathodoluminescence is commonly used to pre-screen geological samples and combined with other SEM techniques for in-depth study. Various CL imaging modes can ...

The development of high throughput electron microscopy techniques in the last decade has made increasingly large imaging projects possible. Now that systems ...

Eukaryotic cells contain a complex network of membrane-bound organelles where specialized processes of the cell take place.

Cathodoluminescence is a specific form of luminescence caused by ‘free’ electrons (or simply electron propagating through space).

Comparing the morphology of healthy and diseased cells or tissues or examining the effect of drug treatments is extremely important for understanding of the ...

Viruses are microscopic infectious agents that are not able to reproduce outside of their hosts. We associate viruses with a variety of diseases, ranging from ...

Rare-earth elements, also known as REE, are a group of elements, consisting of scandium, yttrium and 15 lanthanide elements.

As we all know, biological creatures are highly complex and three-dimensional. Therefore, it is crucial to capture 3D images of their cell structures to find ...

In cryogenic electron microscopy (cryo-EM) a sample is immobilized by rapid freezing in a process called vitrification.

Previously, we have briefly touched on the concept of throughput of electron microscopy workflows.

Semiconductors, as a crucial part of electronic devices, have been in focus in materials research in the last few decades.

Cryogenic electron tomography (cryo-ET) is an imaging technique that uses a cryo Transmission Electron Microscope (cryo-TEM) to acquire high-resolution 3D ...

One of the struggles of imaging facilities today is managing a large number of research projects simultaneously.

What is time-resolved cathodoluminescence? How can performing lifetime mapping or a g(2) mapping add value to your research? In the video below Toon Coenen, ...

Understanding the effects of the SEM parameters on generating (incoherent) cathodoluminescence (CL) is essential for obtaining high-quality CL intensity maps ...

Cathodoluminescence is a great tool for obtaining valuable information about the properties of a sample, which can empower researchers and developers with a ...

For decades, electron microscopes have proven to be great tools for resolving structures at a nanometer scale.

Over the past decades, researchers have been dedicated to studying the beta cells in the islets of Langerhans in order to better understand Diabetes Type 1, ...

Are you interested in the possibilities of cathodoluminescence (CL) for photovoltaics (PV)?

A copper indium gallium selenide (or CIGS), a direct bandgap semiconductor is being commonly used for solar cell production.

Plasmons have gained a lot of interest for their ability to strongly confine light to very small volumes, which makes the field of plasmonics so attractive.

Time-resolved cathodoluminescence (TRCL) is a very powerful and relatively new method for studying emission lifetime dynamics in materials. Discover here how ...

In our previous blog posts, we have already explained the concepts of cathodoluminescence, a powerful technique for materials and nanophotonics structures ...

One of the fastest and most straightforward techniques for understanding the composition and structure of geological samples is intensity mapping.

When adding the new equipment to the lab, it is important to consider a lot of various factors.

For the past few weeks we have been focusing on possibilities of cathodoluminescence imaging of the SPARC CL detector. In this post we describe hyperspectral ...

In the last blog post we explained angle-resolved cathodoluminescence imaging, a technique which is used to acquire angular profiles and gain a better ...

If you are working in the field of photovoltaics or optoelectronics, you know that perovskites, a group of materials that have ABX3 composition and a ...

Studying the formation of sedimentary rocks, observing changes in the chemical composition of zircons, and understanding underlying causes for luminescence of ...

Integrated correlative light and electron microscopy (iCLEM) is a technique, in which both fluorescence imaging and electron imaging can be performed on one ...

Nowadays it has become crucial for life scientists to gain structural and functional data about the sample in order to understand the biological processes ...

Understanding the relationship between structure and function in biology requires continuous developments in the field of microscopy.

In order to make new discoveries in the life sciences, innovations need to be continuously made in microscopy. This way, scientists can take an ever-closer ...

Scientists of all fields are most certainly familiar with the miniature worlds unearthed by electron microscopy.

Characterization at the nanoscale is becoming increasingly important as new discoveries are made and structures are developed at smaller scales. Optical ...

Choosing for the right correlative light and electron microscope can be a challenge. It is a sizeable investment in terms of time and funding. Furthermore, as ...

Those who understand the basic mechanisms of cathodoluminescence (CL) know that it is essentially a useful byproduct of electron microscopy.

It is rare that scientific research will rely on a single method. Instead, findings need to be built on multiple types of data to ensure accuracy.

In 1897, the electron was discovered by Sir Joseph John Thomson. The physicist and eventual Nobel Prize winner was in fact conducting research on “cathode ...

As a researcher in the life sciences, your work will very likely involve studying various parts of a cell at small length scales.